| Bioactivity | KALA is an amphiphilic peptide that forms an α-helical structure at physiological pH. KALA modifies a plasmid DNA-encapsulating liposomal membrane and is used as a fusogenic peptide in order to achieve effective liver targeting and transfection of DNA via galactose receptors[1]. | ||||||
| Invitro | When a plasmid DNA-encapsulating liposomal membrane is modified with the KALA peptide, transgene expression and immune activation are facilitated in bone marrow-derived dendritic cells (BMDCs)[1]. | ||||||
| Name | KALA | ||||||
| CAS | 187987-64-0 | ||||||
| Sequence | Trp-Glu-Ala-Lys-Leu-Ala-Lys-Ala-Leu-Ala-Lys-Ala-Leu-Ala-Lys-His-Leu-Ala-Lys-Ala-Leu-Ala-Lys-Ala-Leu-Lys-Ala-Cys-Glu-Ala | ||||||
| Shortening | WEAKLAKALAKALAKHLAKALAKALKACEA | ||||||
| Formula | C144H248N40O35S | ||||||
| Molar Mass | 3131.82 | ||||||
| Appearance | Solid | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light, under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) |
||||||
| Reference | [1]. Naoya Miura, et al. Identification and Evaluation of the Minimum Unit of a KALA Peptide Required for Gene Delivery and Immune Activation. J Pharm Sci. 2017 Oct;106(10):3113-3119. |
KALA
CAS: 187987-64-0 F: C144H248N40O35S W: 3131.82
KALA is an amphiphilic peptide that forms an α-helical structure at physiological pH. KALA modifies a plasmid DNA-encap
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.