| Bioactivity | α-Conotoxin SIA is a selective nicotinic acetylcholine receptor (nAChR) antagonist with high affinity for the muscle nAChR. α-Conotoxin SIA preferentially targets the α/δ interface of the muscle nAChR in mouse muscle. In contrast, for Torpedo nAChR, α-Conotoxin SIA has a much higher affinity for the α/γ than for the α/δ interface[1]. |
| Name | α-Conotoxin S IA |
| CAS | 135190-31-7 |
| Shortening | YCCHPACGKNFDC-NH2 (Disulfide bridge:Cys2-Cys7;Cys3-Cys13) |
| Formula | C60H82N18O17S4 |
| Molar Mass | 1455.66 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Layla Azam, et al. Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors. Acta Pharmacol Sin. 2009 Jun;30(6):771-83. |
α-Conotoxin S IA
CAS: 135190-31-7 F: C60H82N18O17S4 W: 1455.66
α-Conotoxin SIA is a selective nicotinic acetylcholine receptor (nAChR) antagonist with high affinity for the muscle nA
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