α-Conotoxin PeIA_product_DataBase

Bioactivity	α-Conotoxin PeIA is an analgesic α-conotoxin.α-Conotoxin PeIA inhibits the α6β4, α9α10 and α3β2 nAChR.α-Conotoxin PeIA is also a potent inhibitor of N-type calcium channel via GABAB receptor activation[1][2][3].
Name	α-Conotoxin PeIA
CAS	866876-88-2
Sequence	Gly-Cys-Cys-Ser-His-Pro-Ala-Cys-Ser-Val-Asn-His-Pro-Glu-Leu-Cys-NH2 (Disulfide bridge: Cys2-Cys8, Cys3-Cys16)
Shortening	GCCSHPACSVNHPELC-NH2 (Disulfide bridge: Cys2-Cys8, Cys3-Cys16)
Formula	C65H98N22O21S4
Molar Mass	1651.87
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Daly NL, et al. Structure and activity of alpha-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABA(B) receptor-coupled N-type calcium channels. J Biol Chem. 2011 Mar 25;286(12):10233-7. [2]. Hone AJ, et al. Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors. J Biol Chem. 2018 Nov 16;293(46):17838-17852. [3]. Bony AR, et al. Analgesic α-conotoxins modulate native and recombinant GIRK1/2 channels via activation of GABAB receptors and reduce neuroexcitability. Br J Pharmacol. 2022 Jan;179(1):179-198.

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