| Bioactivity | α-Conotoxin Bt1.8 is a potent α6/α3β2β3 and α3β2 nAChRs inhibitor with IC50s of 2.1 nM and 9.4 nM against rat α6/α3β2β3 and α3β2, respectively[1]. |
| Target | IC50: 2.1 nM (rat α6/α3β2β3), 9.4 nM (rat α3β2), 2150 nM (α3β4) |
| Name | α-Conotoxin Bt1.8 |
| Sequence | Gly-Cys-Cys-Ser-Asn-Pro-Ala-Cys-Ile-Leu-Asn-Asn-Pro-Asn-Gln-Cys-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys16) |
| Shortening | GCCSNPACILNNPNQC-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys16) |
| Formula | C63H100N22O22S4 |
| Molar Mass | 1645.86 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ning H, et al. α-Conotoxin Bt1.8 from Conus betulinus selectively inhibits α6/α3β2β3 and α3β2 nicotinic acetylcholine receptor subtypes. J Neurochem. 2021 Oct;159(1):90-100. |