β-Endorphin (1-27) (human)_product_DataBase

Bioactivity	β-Endorphin (1-27) (human) is an opioid antagonist that binds μ-, δ-, and κ-opioid receptors with Kis of 5.31, 6.17, and 39.82 nM, respectively. β-Endorphin (1-27) (human) inhibits β-Endorphin (HY-P1502)-induced and etorphine-induced analgesia[1][2].
Target	Ki: 5.31 nM (μ-opioid receptor), 6.17 nM (δ-opioid receptor), 39.82 nM (κ-opioid receptor)
Name	β-Endorphin (1-27) (human)
CAS	76622-84-9
Sequence	Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr
Shortening	YGGFMTSEKSQTPLVTLFKNAIIKNAY
Formula	C139H217N33O40S
Molar Mass	3022.47
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Mansour A, et al. The cloned mu, delta and kappa receptors and their endogenous ligands: evidence for two opioid peptide recognition cores. Brain Res. 1995 Nov 27;700(1-2):89-98. [2]. Nicolas P, et al. Beta-endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia. Proc Natl Acad Sci U S A. 1985 May;82(10):3178-81.

PeptideDB