| Bioactivity | yGsy2p-IN-H23 is a potent and first-in-class inhibitor for yeast glycogen synthase 2 (yGsy2p) with an IC50 of 875 µM for human glycogen synthase 1 (hGYS1). yGsy2p-IN-H23 bounds within the uridine diphosphate glucose binding pocket of yGsy2p. yGsy2p-IN-H23 is used for the research of glycogen storage diseases (GSDs)[1]. | ||||||||||||
| Target | IC50: 875 µM (hGYS1) | ||||||||||||
| Invitro | yGsy2p-IN-H23 (compound H23) has IC50 values against either hGYS1Δ634S8,11N or wild-type hGYS1 were 161 μM and 875 µM, respectively. yGsy2p-IN-H23 exhibits IC50 values of 280 µM and 263 µM in the absence and presence of G6P for yGsy2p against yeast and human glycogen synthase (GS), respectively. yGsy2p-IN-H23 is not in direct competition with G6P[1]. | ||||||||||||
| Name | yGsy2p-IN-H23 | ||||||||||||
| CAS | 1269190-98-8 | ||||||||||||
| Formula | C23H27N3O2 | ||||||||||||
| Molar Mass | 377.48 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Buyun Tang, et al. Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase. J Med Chem. 2020 Apr 9;63(7):3538-3551. |
yGsy2p-IN-H23
CAS: 1269190-98-8 F: C23H27N3O2 W: 377.48
yGsy2p-IN-H23 is a potent and first-in-class inhibitor for yeast glycogen synthase 2 (yGsy2p) with an IC50 of 875 µM fo
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