SMS2-IN-2_product_DataBase

CAS: 2241838-28-6 F: C19H13ClFN3O2 W: 369.78

SMS2-IN-2 is a potent, highly selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with IC50s of 100 n

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity

SMS2-IN-2 is a potent, highly selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with IC50s of 100 nM and 56 μM for SMS2 and SMS1, respectively. Anti-chronic inflammatory activity[1].

Target

IC50: 100 nM (SMS2), 56 μM (SMS1)

In Vivo

SMS2-IN-2 (Compound 15w; 20, 50 mg/kg/day, p.o. for 6 weeks) reduces chronic inflammation in the db/db mice[1]. Animal Model:

Name

SMS2-IN-2

CAS

2241838-28-6

Formula

C19H13ClFN3O2

Molar Mass

369.78

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Mo M, et al. Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice. J Med Chem. 2018 Sep 27;61(18):8241-8254.

PeptideDB

SMS2-IN-2

CAS: 2241838-28-6 F: C19H13ClFN3O2 W: 369.78