w-Conotoxin SVIB_product_DataBase

Bioactivity	w-Conotoxin SVIB is a peptide toxin, it can be isolated from Conus venoms. w-Conotoxin SVIB inhibits twitch response with an IC50 value of 37 nM. w-Conotoxin SVIB induces respiratory distress and it can be lethal to mice at a high concentration[1][2].
Target	IC50: 37 nM (twitch response at 0.1 Hz)
Invitro	w-Conotoxin SVIB (0.1-1000 nM; 20 min) inhibits twitch response at 0.1 Hz with an IC50 value of 37 nM[2].
In Vivo	w-Conotoxin SVIB (20 pmol/g; s.c. once) causes paralysis and death in fish[1].w-Conotoxin SVIB causes mouse respiratory distress at around 70 pmol/g and it is lethal to mouse at around 300 pmol/g[1].
Name	w-Conotoxin SVIB
CAS	150433-82-2
Shortening	CKLKGQSCRKTSYDCCSGSCGRSGKC-NH2 (Disulfide bridge: Cys1-Cys16;Cys8-Cys20;Cys15-Cys26)
Formula	C105H176N38O36S6
Molar Mass	2739.14
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ramilo CA, et al. Novel alpha- and omega-conotoxins from Conus striatus venom. Biochemistry. 1992 Oct 20;31(41):9919-26. [2]. Hong SJ, et al. Inhibition of neuromuscular transmission in the myenteric plexus of guinea-pig ileum by omega-conotoxins GVIA, MVIIA, MVIIC and SVIB. Br J Pharmacol. 1996 Jun;118(3):797-803.

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