| Bioactivity | Etofenprox is an orally active non-ester pyrethroid insecticide. Etofenprox induces toxicity against many pest insects, including Diptera rather than mammalian and fish. Etofenprox has a liver tumor-promoting activity in rats accompanied with microsomal ROS production increase. Etofenprox can be used in agricultural pest control and malaria research[1][2]. | ||||||||||||
| Invitro | 埃托芬酯对家蝇有诱导毒性作用，半致死量 (LD50) 为 23 ng/只[1]。 | ||||||||||||
| In Vivo | 埃托芬酯 (粉末: 0.25, 0.5，和 1%; 每日口服, 共 8 天) 对 F344 雄性大鼠的肝脏肿瘤有促进作用，表明 CAR 受体激活，微粒体 ROS 生成增加，导致 Nrf2 基因上调[2]。 | ||||||||||||
| Name | Etofenprox | ||||||||||||
| CAS | 80844-07-1 | ||||||||||||
| Formula | C25H28O3 | ||||||||||||
| Molar Mass | 376.49 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Hemingway J. Efficacy of etofenprox against insecticide susceptible and resistant mosquito strains containing characterized resistance mechanisms. Med Vet Entomol. 1995 Oct;9(4):423-6. [2]. Hojo Y, et al. Liver tumor promoting effect of etofenprox in rats and its possible mechanism of action. J Toxicol Sci. 2012;37(2):297-306. |