sEH/AChE-IN-4_product_DataBase

CAS: 2490589-12-1 F: C35H39ClF3N5O3 W: 670.16

sEH/AChE-IN-4 (compound (+)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and ACh

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	sEH/AChE-IN-4 (compound (+)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 3.1 nM (hsEH), 1660 nM (hAChE), 179 nM (hBChE, human butyrylcholinesterase), 14.5 nM (msEH), and 102 nM (mAChE), respectively[1].
Target	IC50: 3.1 nM (hsEH), 1660 ± 450 nM (hAChE), 179 ± 26 nM (hBChE), 14.5 nM (msEH), 102 ± 18 nM (mAChE)
Name	sEH/AChE-IN-4
CAS	2490589-12-1
Formula	C35H39ClF3N5O3
Molar Mass	670.16
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Codony S, et al. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. J Med Chem. 2022 Mar 24;65(6):4909-4925.

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