| Bioactivity | sEH inhibitor-16 is a soluble epoxide hydrolase (sEH) inhibitors with an IC50 of 2 nM. sEH inhibitor-16 reduces the inflammatory damage in Cerulein (HY-A0190)-induced acute pancreatitis (AP) in mice and can be used for inflammation/immunology research[1]. |
| Target | IC50: 2 nM (sEH) |
| In Vivo | sEH inhibitor-16 (Compound 28) (10 mg/kg，腹腔注射) 对 Cerulein (HY-A0190) 诱导的小鼠急性胰腺炎具有保护作用[1]。sEH inhibitor-16 (Compound 28) (10 mg/kg，腹腔注射) 显示在 CD-1 小鼠中 T1/2 为 7.6 小时，Cmax 为 4.17 ng/mL[1]。 Animal Model: |
| Name | sEH inhibitor-16 |
| Formula | C30H37N3O |
| Molar Mass | 455.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Musella S, et.al. Design, Synthesis, and Pharmacological Characterization of a Potent Soluble Epoxide Hydrolase Inhibitor for the Treatment of Acute Pancreatitis. J Med Chem. 2023 Jul 13;66(13):9201-9222. |