| Bioactivity | p53-MDM2-IN-6, a LSM-83177 hydrazone analog, is a potent p53-MDM2 inhibitor with an IC50 value of 11.08 µg/mL. p53-MDM2-IN-6 arrests the cell cycle in the S phase and induces early and late Apoptosis with antiproliferative activity against HT29 cell lines with an IC50 value of 10.44 µg/mL. p53-MDM2-IN-6 inhibits p53-MDM2 interaction with increment in p-53 level and decrease the expression of GST enzymes. p53-MDM2-IN-6 is promising for research of colorectal cancer[1]. |
| CAS | 1054506-59-0 |
| Formula | C17H17N3O4 |
| Molar Mass | 327.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Elgohary MK, et al. Development of new LSM-83177 analogues as anti-tumor agents against colorectal cancer targeting p53-MDM2 interaction. Bioorg Chem. 2024 Aug 28;153:107766. |
p53-MDM2-IN-6
CAS: 1054506-59-0 F: C17H17N3O4 W: 327.33
p53-MDM2-IN-6, a LSM-83177 hydrazone analog, is a potent p53-MDM2 inhibitor with an IC50 value of 11.08 µg/mL. p53-MDM2
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