| Bioactivity | D5R agonist 1 (Compound 5j) is a selective, orally active and BBB penetrable D5R partial agonist (EC50: 269.7 nM). D5R agonist 1 enhances the cognition in the Scopolamine (HY-N0296)-induced amnesia model[1]. |
| In Vivo | D5R agonist 1 (20 mg/kg, p.o., C57BL/6j mice) 血浆 Tmax: 1 h, Cmax: 51.10 ± 13.51 ng/mL; Brain Tmax: 0.5 h, Cmax: 22.54 ± 4.08 ng/mL)[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C19H18IN3O3 |
| Molar Mass | 463.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kumar S, et al. Discovery and structure - activity relationships of 2,4,5-trimethoxyphenyl pyrimidine derivatives as selective D5 receptor partial agonists. Bioorg Chem. 2024 Sep 7;153:107809. |