p53-MDM2-IN-5_product_DataBase

Bioactivity	p53-MDM2-IN-5 (compound 5a) is a potent p53-MDM2 inhibitor. p53-MDM2-IN-5 induces apoptosis, autophagy and DNA damage. p53-MDM2-IN-5 induces cell cycle arrest at S and G2/M phases. p53-MDM2-IN-5 shows anti-tumor activity[1].
Invitro	p53-MDM2-IN-5 (compound 5a) (1-5 µM; 24 h) 诱导 A549 细胞凋亡，细胞周期停滞在 S 和 G2/M 期[1]。p53-MDM2-IN-5 (1, 5 µM; 24 h) 通过降低 SQSTM1/p62 的表达来诱导自噬[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> p53-MDM2-IN-5 相关抗体: Cell Viability Assay[1] Cell Line:
In Vivo	p53-MDM2-IN-5 (6 μmol/kg; i.v.; every 3 days for 21 days) 在 A549 异种移植裸鼠模型中显示出抗肿瘤活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	2750075-06-8
Formula	C33H37Cl4F2N5O6Pt
Molar Mass	974.57
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Liu W, et al. Discovery of Novel p53-MDM2 Inhibitor (RG7388)-Conjugated PlatinumIV Complexes as Potent Antitumor Agents. J Med Chem. 2024 Jun 13;67(11):9645-9661.

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