Bioactivity | p38α inhibitor 4 (compound 10) is a selective and allosteric p38α inhibitor with an IC50 value of 1.2 μM. p38α inhibitor 4 exhibits no activity against p38β, p38γ, and p38δ[1]. |
Name | p38α inhibitor 4 |
CAS | 1262406-08-5 |
Formula | C14H7F6N3O |
Molar Mass | 347.22 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. ACS Chem. Biol., Article ASAPDOI: 10.1021/cb1002619Publication Date (Web): November 23, 2010 [2]. Kenneth M Comess, et al. Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases. ACS Chem Biol. 2011 Mar 18;6(3):234-44. |