Smurf1-IN-1_product_DataBase

Bioactivity	Smurf1-IN-1 is an orally active and selective inhibitor of specific E3 ubiquitin protein ligase 1 (SMURF1) with an IC50 of 92 nM. Smurf1-IN-1 has significant efficacy in rats model of pulmonary hypertension[1].
Target	IC50: 92 nM Specific E3ubiquitin protein ligase 1 (SMURF1)
In Vivo	Smurf1-IN-1 (Compound 38) (1，3，10 mg/kg，口服) 对大鼠肺部高压模型有显著疗效[1]。Smurf1-IN-1 (静脉注射1 mg/kg，口服 3 mg/kg) 显示 T1/2 为 7.9 小时，口服生物利用度 (F%) 为 82%[1]。 Animal Model:
Name	Smurf1-IN-1
CAS	1824708-03-3
Formula	C24H29ClN6O2
Molar Mass	468.98
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Shaw DE, et.al. Design and Synthesis of Inhibitors of the E3 Ligase SMAD Specific E3 Ubiquitin Protein Ligase 1 as a Treatment for Lung Remodeling in Pulmonary Arterial Hypertension. J Med Chem. 2023 Jun 22;66(12):8130-8139.

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