| Bioactivity | iHAC is an inhibitor HSP90-anchoring chimera, that covalently binds BRD4 ligand (+)-JQ-1 to HSP90, and inhibits the proliferation of cancer cells. iHAC activates the anti-tumor immune response, inhibits the recurrence and metastasis of 4T1 breast cancer in mouse models[1]. |
| Formula | C50H46ClIN16O7S3 |
| Molar Mass | 1241.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen Y, et al., Engineered platelets as targeted protein degraders and application to breast cancer models. Nat Biotechnol. 2024 Dec 3. Epub ahead of print. Erratum in: Nat Biotechnol. 2025 Jan 13. |