| Bioactivity | FLT3-IN-29 (Compound MY-10) is a FLT3 inhibitor (IC50s: 6.5 and 10.3 nM for FLT3-ITD and FLT3-D835Y mutants). FLT3-IN-29 arrests cell cycle at the G0/G1 phase and efficiently induces Apoptosis. FLT3-IN-29 also reduces reactive oxygen species (ROS) production and mitochondrial membrane potential (MMP). FLT3-IN-29 displays antileukemic activity[1]. |
| Invitro | FLT3-IN-29 对 MV4-11 细胞具有良好的抗增殖活性 (IC50 = 0.59 μM)[1]。FLT3-IN-29 (0.2-10 μM, 24 h) 可使细胞周期停滞在 G0/G1 期，诱导细胞凋亡，并降低 MV4-11 细胞中的 ROS 水平[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> FLT3-IN-29 相关抗体: |
| Formula | C25H30N6O2 |
| Molar Mass | 446.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liu W, et al. Discovery of 3-amide-pyrimidine-based derivatives as potential fms-like tyrosine receptor kinase 3 (FLT3) inhibitors for treating acute myelogenous leukemia. Bioorg Med Chem Lett. 2024 Dec 19;117:130082. |