| Bioactivity | hMAO-B-IN-4 (compound B10) is a selective, reversible and blood–brain barrier (BBB) penetrable human monoamine oxidase-B (hMAO-B) inhibitor with an IC50 value and a Ki value of 0.067 and 0.03 μM, respectively. hMAO-B-IN-4 inhibits hMAO-A with an IC50 value of 33.82 μM. hMAO-B-IN-4 can be used for Alzheimer’s disease (AD) and Parkinson’s disease (PD) research[1]. | ||||||||||||
| Invitro | hMAO-B-IN-4 (0-40 μM) 对 hMAO-B 相比于 hMAO-A 具有高选择性，SI 值为 504.791[1]。hMAO-B-IN-4 (0-40 μM) 抑制 hMAO-A 和 hMAO-B，IC50 值分别为 33.821 和 0.067 μM[1]。 | ||||||||||||
| Name | hMAO-B-IN-4 | ||||||||||||
| CAS | 1666119-75-0 | ||||||||||||
| Formula | C20H16O2S | ||||||||||||
| Molar Mass | 320.40 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Sudevan ST, et al. Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors. Sci Rep. 2022 Dec 27;12(1):22404. |
hMAO-B-IN-4
CAS: 1666119-75-0 F: C20H16O2S W: 320.40
hMAO-B-IN-4 (compound B10) is a selective, reversible and blood–brain barrier (BBB) penetrable human monoamine oxidase-
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