| Bioactivity | ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders[1]. |
| Target | IC50: 13.5 nM (MCH1R); >10000 nM (MCH2R). |
| Invitro | ATC0175 shows affinity for 5-HT2B and 5-HT1A with IC50s of 9.66 and 16.9 nM respectively[1]. |
| In Vivo | ATC0175 (1, 3, 10 mg/kg; p.o.) significantly and dose-dependently reduces immobility time, indicating antidepressant like potential[1]. |
| Name | ATC0175 |
| CAS | 510733-97-8 |
| Formula | C23H26ClF2N5O |
| Molar Mass | 461.94 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chaki S, Yamaguchi J, Yamada H, Thomsen W, Tran TA, Semple G, Sekiguchi Y. ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. CNS Drug Rev. 2005 Winter;11(4):341-52. |
ATC0175
CAS: 510733-97-8 F: C23H26ClF2N5O W: 461.94
ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5,
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