| Bioactivity | HGPR91 antagonist 1 is a potent and selective small molecule hGPR91 antagonist with an IC50 of 7 μM[1]. | ||||||||||||
| Target | IC50: 7 μM (HGPR91) | ||||||||||||
| In Vivo | HGPR91 antagonist 1 leads to 59, 76% inhibition of ΔMAP at 2, 4 hours and has shown rat plasma protein binding 99%. HGPR91 antagonist 1 has engaged the target under the in vivo condition. HGPR91 antagonist 1 has clearance (CL) of 0.2 nmol/min/mg of RLM[1]. Animal Model: | ||||||||||||
| Name | hGPR91 antagonist 1 | ||||||||||||
| CAS | 1314796-00-3 | ||||||||||||
| Formula | C31H23F4N3O | ||||||||||||
| Molar Mass | 529.53 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Bhuniya D, et al. Discovery of a potent and selective small molecule hGPR91 antagonist. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3596-602. |