AMP-PNP tetralithium_product_DataBase

Bioactivity	AMP-PNP tetralithium (Adenylyl-imidodiphosphate tetralithium) is a non-hydrolysable analogue of ATP and inhibits KATP channels[1][2].
Invitro	AMP-PNP (5 to 500 μM; Li salt) reduced the open-probability po of KATP channels and decreases the single-channel currents at high nucleotide concentrations by approximately 10%[2].AMP-PNP inhibits KATP channels of ventricular myocytes and of pancreatic β-cells both in the absence and presence of Mg2+ ions[2].
Name	AMP-PNP tetralithium
CAS	72957-42-7
Formula	C10H13Li4N6O12P3
Molar Mass	529.93
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. I M Rybakowska, et al. Activities of purine converting enzymes in heart, liver and kidney mice LDLR-/- and Apo E-/. Nucleosides Nucleotides Nucleic Acids. 2018;37(6):340-347. [2]. S Hehl, et al. KATP channels of mouse skeletal muscle: mechanism of channel blockage by AMP-PNP. Eur Biophys J. 1994;23(4):231-7.

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