| Bioactivity | hDHODH-IN-16 (Compound 3t) is a human dihydroorotate dehydrogenase (hDHODH) inhibitor, with an IC50 of 0.11 μM. hDHODH-IN-16 shows very low cytotoxicity to healthy HaCaT cells, with an IC50 value greater than 200 µM[1]. |
| Formula | C18H20N2O2 |
| Molar Mass | 296.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Marina G Dimitrijević, et al. Discovery of a new class of potent pyrrolo[3,4-c]quinoline-1,3-diones based inhibitors of human dihydroorotate dehydrogenase: Synthesis, pharmacological and toxicological evaluation. Bioorg Chem. 2024 Jun:147:107359. |