| Bioactivity | hCAIX/XII-IN-8 (compound 3g) is a potent human (carbonic anhydrase) CA IX and XII inhibitor, with Ki values of 8.5 and 6.7 nM, respectively. hCAIX/XII-IN-8 shows particularly strong inhibitory activity against the tumor-associated membrane-bound isoforms, hCA IX and XII, while maintaining a high selectivity ratio over cytosolic off-target isoforms hCA I and II[1]. |
| Name | hCAIX/XII-IN-8 |
| CAS | 59994-64-8 |
| Formula | C16H13Cl2N5O3S |
| Molar Mass | 426.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Akocak S, et al. Potent and selective carbonic anhydrase inhibition activities of pyrazolones bearing benzenesulfonamides. Bioorg Med Chem Lett. 2023 Oct 15;95:129479. |
hCAIX/XII-IN-8
CAS: 59994-64-8 F: C16H13Cl2N5O3S W: 426.28
hCAIX/XII-IN-8 (compound 3g) is a potent human (carbonic anhydrase) CA IX and XII inhibitor, with Ki values of 8.5 and 6
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.