| Bioactivity | hCAII/hCAIX-IN-1 (compound 4o) is a potent inhibitor of hCAII and hCAIX, with the Kis of 7.4 and 7.0 nM, respectively. hCAII/hCAIX-IN-1 plays an important role in cancer research[1]. |
| Formula | C23H22N4O7S2 |
| Molar Mass | 530.57 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cristina M Al-Matarneh, et al. Novel 3-Sulfonamide Dual-Tail Pyrrol-2-one Bridged Molecules as Potent Human Carbonic Anhydrase Isoform Inhibitors: Design, Synthesis, Molecular Modeling Investigation, and Anticancer Activity in MeWo, SK-BR-3, and MG-63 Cell Lines. J Med Chem. 2025 Jan 10. doi: 10.1021/acs.jmedchem.4c02586. |