| Bioactivity | hAChE-IN-2 is a potent hAChE inhibitor, with an IC50 of 0.71 μM. hAChE-IN-2 can also inhibits tau-oligomerization, with an EC50 of 2.21 μM. hAChE-IN-2 exhibits neuroprotective activity[1]. |
| Invitro | hAChE-IN-2 (compound 21) (1-10 μM) shows neuroprotective activity in SH-SY5Y cells transfected with WT tau[1]. |
| Name | hAChE-IN-2 |
| Formula | C22H23FN4O2 |
| Molar Mass | 394.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Madhav H, et, al. Multicomponent Petasis reaction for the identification of pyrazine based multi-target directed anti-Alzheimer's agents: In-silico design, synthesis, and characterization. Eur J Med Chem. 2023 Jun 5;254:115354. |