| Bioactivity | MU380 is a potent and selective CHK1 inhibitor that induces apoptosis and has anticancer activity[1]. |
| Invitro | MU380 (100 nM, 24 h) 有效抑制 CHK1 激酶并使淋巴肿瘤细胞对吉西他滨敏感[1]。 MU380 (400 nM, 24 h) 可以显着影响细胞周期概况，诱导分裂和非分裂原发性慢性淋巴细胞白血病淋巴细胞死亡[1]。 Apoptosis Analysis[1] Cell Line: |
| In Vivo | MU380 (20 mg/kg, in 20% aqueous Kolliphor solution, every three days from day 14 to day 28) 可以有效抑制小鼠肿瘤的生长[1]。 Animal Model: |
| Name | MU380 |
| CAS | 2109805-78-7 |
| Formula | C15H15BrF3N7 |
| Molar Mass | 430.23 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Miroslav Boudny, et al. Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells. Haematologica. 2019 Dec;104(12):2443-2455. |