| Bioactivity | eIF4A3-IN-13 (compound 75) is a silvestrol (HY-13251) analogue. eIF4A3-IN-13 interferes the assembling of eIF4F translation complex with EC50s of 0.6, 15 and 0.4 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-13 can be used for the research of human cancer pathogenesis[1]. |
| Name | eIF4A3-IN-13 |
| CAS | 1402931-85-4 |
| Formula | C28H28ClNO6 |
| Molar Mass | 509.98 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78. |
eIF4A3-IN-13
CAS: 1402931-85-4 F: C28H28ClNO6 W: 509.98
eIF4A3-IN-13 (compound 75) is a silvestrol(HY-13251) analogue. eIF4A3-IN-13 interferes the assembling of eIF4F translati
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