| Bioactivity | dBET6 is a highly potent, selective and cell-permeable PROTAC connected by ligands for Cereblon and BET, with an IC50 of 14 nM, and has antitumor activity. | |||||||||
| Invitro | dBET6 is a highly potent, selective and cell-permeable degrader of BET with an IC50 of 14 nM. dBET6 (100 nM) exhibits antitumor activity against T cell acute lymphoblastic leukemia (T-ALL) lines via degradation of BRD4[1]. | |||||||||
| Name | dBET6 | |||||||||
| CAS | 1950634-92-0 | |||||||||
| Formula | C42H45ClN8O7S | |||||||||
| Molar Mass | 841.37 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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dBET6
CAS: 1950634-92-0 F: C42H45ClN8O7S W: 841.37
dBET6 is a highly potent, selective and cell-permeable PROTAC connected by ligands for Cereblon and BET, with an IC50 of
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