Oxidopamine hydrochloride_product_DataBase

Bioactivity	Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrochloride is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrochloride promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrochloride can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome[1][2][3][4].
Invitro	Oxidopamine hydrochloride (0-500 µM, 24 h) decreases the viability of both Neuro-2a cells and SH-SY5Y cells in a concentration-dependent manner[1].Oxidopamine hydrochloride (75-150 µM, 0-24 h) induces COX-2 expression and nuclear translocation[1].Oxidopamine hydrochloride (75-150 µM, 0-24 h) causes PGE2 biosynthesis and pro-inflammatory cytokine IL-1β production[1].Oxidopamine hydrochloride (0-150 μM, 12 h) induces apoptosis and mitochondrial membrane depolarization of pheochromocytoma PC12 cells[3].Oxidopamine hydrochloride (75 μM, 0-12 h) induces p38 phosphorylation[3]. Cell Viability Assay[1] Cell Line:
Name	Oxidopamine hydrochloride
CAS	28094-15-7
Formula	C8H12ClNO3
Molar Mass	205.64
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, stored under nitrogen *该产品在溶液状态不稳定，建议您现用现配，即刻使用。

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