| Bioactivity | ZXH-8-004 (2-12-2-deg) is a potent DENV E PROTAC degrader with an DC50 value of 0.21 µM. ZXH-8-004 shows exhibit antiviral potencies (Blue: E3 ligase (HY-103596), Black: linker (HY-42149); Pink: DENV E ligand (HY-161807))[1]. |
| Formula | C38H33F6N7O10 |
| Molar Mass | 861.70 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liu HY, et al. Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism. Nat Commun. 2024 Jun 19;15(1):5179. |