| Bioactivity | IGF-1R modulator 1 (Example 5) is an IGF-1R modulator, with EC50s of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), 0.39 μM (TrkB). IGF-1R modulator 1 can be used for research of diseases characterised by impaired signalling of neurotrophins and/or other trophic factors, such as Alzheimer's disease[1]. |
| Target | EC50: 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), 0.39 μM (TrkB) |
| CAS | 2375424-89-6 |
| Formula | C22H17N3O4 |
| Molar Mass | 387.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gunnar Nordvall, et al. Triazine derivatives for treating diseases relating to neurotrophins. Patent. WO2019162702. |
IGF-1R modulator 1
CAS: 2375424-89-6 F: C22H17N3O4 W: 387.39
IGF-1R modulator 1 (Example 5) is an IGF-1R modulator, with EC50s of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA)
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