| Bioactivity | ZX782 is a GPX4 protein degrader and ferroptosis inducer, which consumes GPX4 through the ubiquitin-proteasome and autophagy-lysosome pathways. After GPX4 degradation induced by ZX782, it can significantly increase the accumulation of lipid reactive oxygen species (ROS) in HT1080 cells[1]. |
| Formula | C39H48ClN5O8 |
| Molar Mass | 750.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Design, Synthesis, and Biological Evaluation of Hydrophobic-Tagged Glutathione Peroxidase 4 (GPX4) Degraders |