| Bioactivity | ZT55 is an orally active and highly-selective JAK2 inhibitor with an IC50 value of 0.031 μM. ZT55 inhibits the proliferation of JAK2V617F-expressing HEL cell lines and induces apoptosis and cycle arrest. ZT-55 also effectively inhibits the growth of HEL xenograft tumours in a mice model. ZT-55 can be used in studies of myeloproliferative neoplasms, polycythemia vera and primary thrombocythemia[1]. |
| Invitro | ZT55 (0-100 μM; 48 h) 以浓度依赖的方式对 JAK2V617F 表达阳性的 HEL 细胞显示抗增殖活性 (IC50=18.05 μM)[1]。ZT55 (12.5, 25, 50 μM; 24, 48, 72 h) 以浓度和时间依赖的方式抑制 HEL 细胞的活力并诱导细胞凋亡[1]。ZT55 (12.5, 25, 50 μM; 24 h) 以浓度依赖的方式诱导 HEL 细胞阻滞在 G2/M 期[1]。 Cell Proliferation Assay[1] Cell Line: |
| Name | ZT55 |
| CAS | 2138488-38-5 |
| Formula | C17H16N2O3 |
| Molar Mass | 296.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |