| Bioactivity | ZM600 is a potent and orally active antihepatic fibrosis agent. ZM600 decreases the LPS (HY-D1056) induced protein expression of collagen I, α-SM, p-p65. ZM600 has the potential for the research of liver fibrosis[1]. |
| Invitro | ZM600 对 LX-2 细胞有细胞毒性，IC50 值为 38.17 µM[1]。ZM600 (0、5、10、20 µM；2+48 h) 可降低 LPS (HY-D1056) 和 TGF-β1 诱导的 collagen I 和 α-SM 的蛋白质和 mRNA 表达[1]。ZM600 (0, 5, 10, 20 µM; 2+2 h) 可降低 LPS (HY-D1056) 和 TGF-β1 诱导的 LX-2 细胞中 p-p65、p-Smad2/3 和 p-AKT 的蛋白质表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> ZM600 相关抗体: RT-PCR[1] Cell Line: |
| In Vivo | ZM600 (15, 30 mg/kg; p.o.; daily for 3 weeks) 可减轻 CCl4 诱发的实验性肝纤维化[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C33H41FO3 |
| Molar Mass | 504.68 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li G, et al. Discovery of Sophoridine α-Aryl Propionamide Derivative ZM600 as a Novel Antihepatic Fibrosis Agent. J Med Chem. 2024 Jul 11;67(13):11389-11400. |