| Bioactivity | Necroptosis-IN-4, a potent necroptosis inhibitor, is a RIP kinase 1 (RIPK1) inhibitor. Necroptosis-IN-4 has no inhibitory activity against RIPK3 and weak inhibitory activity against VEGFR1/2 and PDGFR-α[1]. |
| Invitro | Necroptosis-IN-4 (compound 33) 对人类和鼠类细胞均具有强效的抗坏死性凋亡活性（人类 I2.1 细胞：IC50 0 --> Necroptosis-IN-4 相关抗体: |
| In Vivo | Necroptosis-IN-4 在雄性 Sprague-Dawley 大鼠中的药代动力学参数[1]。1.19 Parameter |
| Formula | C26H23F3N6O3 |
| Molar Mass | 524.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yaohan Lan, et al. Discovery and optimization of 3-(indolin-5-yloxy)pyridin-2-amine derivatives as potent necroptosis inhibitors. Arch Pharm (Weinheim). 2024 Jul 2:e2400302. |