| Bioactivity | ZL0590 is a potent, orally active BRD4 BD1-selective inhibitor with an IC50 of 90 nM for human BRD4 BD1. ZL0590 exhibits significant anti-inflammatory activities[1]. | ||||||||||||
| Target | IC50: 90 nM (human BRD4 BD1) | ||||||||||||
| Name | ZL0590 | ||||||||||||
| CAS | 2230496-99-6 | ||||||||||||
| Formula | C23H27F3N4O4S | ||||||||||||
| Molar Mass | 512.55 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Liu Z, et al. Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site. J Med Chem. 2022;65(3):2388-2408. |
ZL0590
CAS: 2230496-99-6 F: C23H27F3N4O4S W: 512.55
ZL0590 is a potent, orally active BRD4 BD1-selective inhibitor with an IC50 of 90 nM for human BRD4 BD1. ZL0590 exhibits
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