| Bioactivity | ZG297 is an agonist for Staphylococcus aureus ClpP (SaClpP ) with an EC50 of 0.26 μM. ZG297 degrades SaFtsZ, inhibits the bacterial cell division, thereby exhibiting antistaphylococcal activity, that inhibits S. aureus 8325-4 strains and MRSA strains with MIC of 0.063-256 μg/mL. ZG297 exhibits anti-infectious efficacy in mouse models[1]. |
| CAS | 2999673-52-6 |
| Formula | C31H35F3N4O3 |
| Molar Mass | 568.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang T, et al., Structure-guided development of selective caseinolytic protease P agonists as antistaphylococcal agents. Cell Rep Med. 2024 Dec 17;5(12):101837. |