| Bioactivity | ZC0101 is a potent, orally active IDO1 and TrxR dual inhibitor with IC50 values of 0.084 μM and 7.98 μM, respectively. ZC0101 effectively induces apoptosis and ROS accumulation in cancer cells[1]. |
| In Vivo | ZC0101 (60 mg/kg; p.o.; once) effectively suppresses IDO1 activity in vivo[1]. |
| Name | ZC0101 |
| CAS | 2541604-52-6 |
| Formula | C17H15N3O2 |
| Molar Mass | 293.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fan QZ, et al. Design, synthesis, and biological evaluation of a novel indoleamine 2,3-dioxigenase 1 (IDO1) and thioredoxin reductase (TrxR) dual inhibitor. Bioorg Chem. 2020 Dec;105:104401. |