Z-Phe-Tyr(tBu)-diazomethylketone_product_DataBase

Bioactivity	Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection[1][2].
Invitro	Z-Phe-Tyr(tBu)-diazomethylketone (3.3, 10 µM; 3 h) 在L929 细胞中导致呼肠孤病毒对病毒外衣壳蛋白的蛋白水解分解效率低下，并降低病毒产量[1]。Z-Phe-Tyr(tBu)-diazomethylketone 在 SARS-CoV-2 感染心肌细胞 (CM) 中将病毒检出率降低至处理对照组的10%[2]。
Name	Z-Phe-Tyr(tBu)-diazomethylketone
CAS	114014-15-2
Formula	C31H34N4O5
Molar Mass	542.63
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ebert DH, et al. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J Biol Chem. 2002 Jul 5;277(27):24609-17. [2]. Perez-Bermejo JA, et al. SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19. Sci Transl Med. 2021 Apr 21;13(590):eabf7872.

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