BMS-929075

CAS: 1217338-97-0 F: C31H24F2N4O3 W: 538.54

BMS-929075 is a potent and orally active HCV NS5B replicase palm site allosteric inhibitor. BMS-929075 shows high oral b

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Bioactivity	BMS-929075 is a potent and orally active HCV NS5B replicase palm site allosteric inhibitor. BMS-929075 shows high oral bioavailability. BMS-929075 shows cytotoxicity[1].
Invitro	BMS-929075 (0-60 µM) 显示细胞毒性，对于 Huh-7、HepG2、原代人肝细胞的CC50 值分别为 60、>12.5、>50 µM[1]。
In Vivo	BMS-929075 (compound 37) (静脉注射 2 mg/kg；口服 6 mg/kg) 显示出良好的药代动力学参数，大鼠口服生物利用度为 48%[1]。
Name	BMS-929075
CAS	1217338-97-0
Formula	C31H24F2N4O3
Molar Mass	538.54
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yeung KS, et al. Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. J Med Chem. 2017 May 25;60(10):4369-4385.

Toonaciliatin M

Z-Phe-Tyr(tBu)-diazomethylketone