| Bioactivity | Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia[1][2]. |
| Invitro | Z-LLNle-CHO (0-5 µM or 0-3 µM; 72 h) results in a dose-dependent decrease in cell viability/proliferation in six breast cancer cell lines[1].Z-LLNle-CHO shows proteasome inhibitory activity, which contributes to cytotoxicity to MCF-7 cells[1].Z-LLNle-CHO blocks Akt-mediated pro-survival pathways and induces caspase- and ROS-dependent cell apoptosis in Nalm6 and 697 cells[2]. Cell Viability Assay[1] Cell Line: |
| Name | Z-LLNle-CHO |
| CAS | 133407-83-7 |
| Formula | C26H41N3O5 |
| Molar Mass | 475.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Z-LLNle-CHO
CAS: 133407-83-7 F: C26H41N3O5 W: 475.62
Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis b
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