| Bioactivity | Yp537 TFA is an estrogen receptor (ER) inhibitor that blocks dimerization of the human estrogen receptor[1]. | ||||||
| Invitro | Yp537 TFA（5-50 μM；1 小时）消除 hER-ERE 复合物的形成。并且不抑制 STAT1-血清诱导的元件复合物的形成[1]。Yp537 TFA 与 SH2-like 结构域结合，干扰 sh2-like 磷酸肽在 hER 单体之间的偶联机制[1]。 | ||||||
| Name | Yp537 TFA | ||||||
| Sequence | Cys-Asn-Val-Val-Pro-Leu-{Tyr(PO3H2)}-Asp-Leu-Leu-Leu-Glu | ||||||
| Shortening | CNVVPL-{Tyr(PO3H2)}-DLLLE | ||||||
| Formula | C66H105F3N13O24PS | ||||||
| Molar Mass | 1584.65 | ||||||
| Appearance | Solid | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light, under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) |
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| Reference | [1]. Arnold SF, et al. An antiestrogen: a phosphotyrosyl peptide that blocks dimerization of the human estrogen receptor. Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7475-9. |