YPC-22026_product_DataBase

Bioactivity	YPC-22026 is a zinc-finger protein 143 (ZNF143) inhibitor with an IC50 value of 9.0 μM. YPC-22026 is a potent tumor regression inducer. YPC-22026 exhibits anti‐tumor activities[1].
Invitro	YPC-22026 (96 小时) 对 HCT116 和 PC-3 具有细胞毒性，IC50 值分别为 0.33 μM 和 0.66 μM[1]。YPC-22026 (3 μM；24 小时) 诱导 G2/M 停滞并降低 ZNF143 与 STAF 结合位点的结合[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> YPC-22026 相关抗体: Cell Cycle Analysis[1] Cell Line:
In Vivo	YPC-22026（50-100 mg/kg；腹腔注射；第 1、2、3、8、9、12 和 16 天）显著抑制 HCT116 异种移植模型中肿瘤的生长[1]。在 PC-3 异种移植模型中，YPC-22026（75 mg/kg；腹腔注射）显著降低所有 ZNF143 靶基因、RAD51、PLK1 和 Survivin 的肿瘤内表达水平[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	1964457-41-7
Formula	C16H8F3N3O2
Molar Mass	331.25
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hirotaka Haibara, et al. YPC-21661 and YPC-22026, novel small molecules, inhibit ZNF143 activity in vitro and in vivo. Cancer Sci. 2017 May;108(5):1042-1048.

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