| Bioactivity | YM-31636 (free base) is an orally active, potent and selective 5-HT3 receptor agonist with a pKi value of 9.67. YM-31636 (free base) induces contraction of isolated guinea pig distal colon. YM-31636 (free base) induces tachycardia with the relative intrinsic activity of approximately 0.23 in isolated guinea pig right atrium. YM-31636 (free base) is promising for research of constipation[1][2]. |
| CAS | 159081-22-8 |
| Formula | C14H11N3S |
| Molar Mass | 253.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ito H, et al. Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro. Eur J Pharmacol. 2000 Dec 8;409(2):195-201. [2]. Kiso T, et al. A novel 5-HT3 receptor agonist, YM-31636, increases gastrointestinal motility without increasing abdominal pain. Eur J Pharmacol. 2001 Nov 9;431(1):35-41. |
YM-31636 free base
CAS: 159081-22-8 F: C14H11N3S W: 253.32
YM-31636 (free base) is an orally active, potent and selective 5-HT3 receptor agonist with a pKi value of 9.67. YM-31636
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