| Bioactivity | YCH3124 (compound Z33) is a USP7 inhibitor (IC50=41.9 nM) with antitumor activity. YCH3124 has good in vitro antiproliferative activity against various tumor cells including LNCaP (IC50=3.6 nM) and CHP-212 (IC50=9.9 nM). In addition, YCH3124 disrupts cell cycle progression by restricting G1 phase and induces apoptosis in CHP-212 cells[1]. |
| Formula | C30H34N4O5 |
| Molar Mass | 530.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhen Zhuang, et al. "Discovery of pyrrolo [2, 3-d] pyrimidin-4-one derivative YCH3124 as a potent USP7 inhibitor for cancer therapy." European Journal of Medicinal Chemistry (2024): 116752. |