| Bioactivity | EP009 is a JAK3 inhibitor. In vitro studies have shown that EP009 is a low-micromolar JAK3 inhibitor that selectively inhibits IL-2-mediated JAK3 tyrosine phosphorylation in Kit225 cells (cellular IC50=10-20 μM) without affecting IL-3-induced JAK2 phosphorylation in BaF/3 cells (up to 50 μM). EP009 significantly reduced Kit225 cell viability (LD50=5.0 μM at 72 hr) while having no effect on BaF/3 cells[1]. |
| Target | JAK3 |
| CAS | 685901-63-7 |
| Formula | C12H14BrN5O5 |
| Molar Mass | 388.17 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Xylocydine
CAS: 685901-63-7 F: C12H14BrN5O5 W: 388.17
EP009 is a JAK3 inhibitor. In vitro studies have shown that EP009 is a low-micromolar JAK3 inhibitor that selectively in
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