Xanthine oxidoreductase-IN-4_product_DataBase

Bioactivity	Xanthine oxidoreductase-IN-4 is an orally active xanthine oxidoreductase (XOR) inhibitor. Xanthine oxidoreductase-IN-4 has inhibitory activity against XOR with an IC50 value of 29.3 nM. Xanthine oxidoreductase-IN-4 can be used for the research of hyperuricemia[1].
Target	IC50: 29.3 nM (XOR)
Invitro	Xanthine oxidoreductase-IN-4 (Compound IIIc) 对 XOR 具有抑制活性，IC50 值为 29.3 nM[1]。
In Vivo	Xanthine oxidoreductase-IN-4 (Compound IIIc) (oral; 5 mg/kg)在恶嗪酸钾/次黄嘌呤诱导的急性高尿酸血症模型中显示出显着的低尿酸血症效应[1]。 Animal Model:
Name	Xanthine oxidoreductase-IN-4
CAS	1026587-58-5
Formula	C16H15N5O2
Molar Mass	309.32
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wen Peng, et al. Design, synthesis, and evaluation of tricyclic compounds containing phenyl-tetrazole as XOR inhibitors. Eur J Med Chem. 2022 Nov 28;246:114947.

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