| Bioactivity | XX-650-23 is a potent CREB inhibitor. XX-650-23inhibits CREB function through disruption of CBP-CREB interaction. XX-650-23 can be used for AML research[1]. |
| Invitro | XX-650-23 (870 nM-2.3 μM) 抑制白血病细胞系的生长，抑制 HL-60、KG-1、MOLM-13 和 MV-4-11 的 IC50 值分别为 870 nM、910 nM、2.0 μM 和 2.3 μM[1]。Xx-650-23 (5 μM; 6 或 24 小时) 引起 H3K27 乙酰化的特异性降低[1]。Xx-650-23 (2 μM; 72 hours) 通过激活 caspase-3 和可检测到的 caspase-9 切割，通过内在凋亡途径诱导细胞凋亡。它还导致 Mcl-1 和 bcl-2 的下调[1]。 Western Blot Analysis[1] Cell Line: |
| Name | XX-650-23 |
| CAS | 117739-40-9 |
| Formula | C18H12N2O2 |
| Molar Mass | 288.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. B Mitton, et al. Small molecule inhibition of cAMP response element binding protein in human acute myeloid leukemia cells. Leukemia. 2016 Dec;30(12):2302-2311. |