| Bioactivity | XOR/URAT1-IN-1 (Compound II15) is a dual inhibitor for xanthine oxidoreductase (XOR) and uric acid transporter 1 (URAT1), with IC50 of 6 nM and 12.9 μM. XOR/URAT1-IN-1 lowers the levels of uric acid in Potassium oxonate (HY-17511)/Hypoxanthine (HY-N0091)-induced acute hyperuricemia mouse model[1]. |
| Target | IC50: 6 nM (XOR), 12.9 μM (URAT1) |
| CAS | 2810137-86-9 |
| Formula | C18H13ClN2O3 |
| Molar Mass | 340.76 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang C, et al., Design, synthesis, and biological evaluation of 3-phenyl substituted pyridine derivatives as potential dual inhibitors of XOR and URAT1. Eur J Med Chem. 2024 May 5;271:116407. |
XOR/URAT1-IN-1
CAS: 2810137-86-9 F: C18H13ClN2O3 W: 340.76
XOR/URAT1-IN-1 (Compound II15) is a dual inhibitor for xanthine oxidoreductase (XOR) and uric acid transporter 1 (URAT1)
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